Observation....
For Helix Floor:
It seems that Helix does not like 12th fret harmonics on some strings when using this offset functionality.
Pluck the open string = performance as you would expect it.
12th fret harmonic = unexpected performance if on the high E, B, and G strings.
For Helix Native
Similar phenomena to the above except acceptance of a 12th fret harmonic is even more random
Moral of the story:
So, if you want to use the offset tuning functionality do not use 12th fret harmonics to make the string ring out. You need to pluck the open string.